The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis

The pathogenesis of SpA is multifactorial and involves a range of immune cell types and cytokines, many of which utilize Janus kinase (JAK) pathways for signaling. In this review, we summarize the animal and pre-clinical data that have demonstrated the effects of JAK blockade on the underlying molec...

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Vydáno v:Rheumatology (Oxford)
Hlavní autoři: Veale, Douglas J, McGonagle, Dennis, McInnes, Iain B, Krueger, James G, Ritchlin, Christopher T, Elewaut, Dirk, Kanik, Keith S, Hendrikx, Thijs, Berstein, Gabriel, Hodge, Jennifer, Telliez, Jean-Baptiste
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Reviews
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343466/
https://ncbi.nlm.nih.gov/pubmed/29618084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/key070
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