Structural Basis for Assembly of the Mn(IV)/Fe(III) Cofactor in the Class Ic Ribonucleotide Reductase from Chlamydia trachomatis

The class Ic ribonucleotide reductase (RNR) from Chlamydia trachomatis (Ct) employs a Mn(IV)/Fe(III) cofactor in each monomer of its β(2) subunit to initiate nucleotide reduction. The cofactor forms by reaction of Mn(II)/Fe(II)-β(2) with O(2). Previously, in vitro cofactor assembly from apo β(2) and...

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Bibliographic Details
Main Authors: Dassama, Laura M.K., Krebs, Carsten, Bollinger, J. Martin, Rosenzweig, Amy C., Boal, Amie K.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821933/
https://ncbi.nlm.nih.gov/pubmed/23924396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400819x
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