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Formation and Function of the Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase
The β(2) subunit of a class Ia or Ib ribonucleotide reductase (RNR) is activated when its carboxylate-bridged Fe(2)(II/II) cluster reacts with O(2) to oxidize a nearby tyrosine (Y) residue to a stable radical (Y•). During turnover, the Y• in β(2) is thought to reversibly oxidize a cysteine (C) in th...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693138/ https://ncbi.nlm.nih.gov/pubmed/19061340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8017625 |
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