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Formation and Function of the Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase

The β(2) subunit of a class Ia or Ib ribonucleotide reductase (RNR) is activated when its carboxylate-bridged Fe(2)(II/II) cluster reacts with O(2) to oxidize a nearby tyrosine (Y) residue to a stable radical (Y•). During turnover, the Y• in β(2) is thought to reversibly oxidize a cysteine (C) in th...

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Detalhes bibliográficos
Main Authors: Jiang, Wei, Yun, Danny, Saleh, Lana, Bollinger, J. Martin, Krebs, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693138/
https://ncbi.nlm.nih.gov/pubmed/19061340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8017625
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