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Radical-translocation Intermediates and Hurdling of Pathway Defects in “Super-oxidized” (Mn(IV)/Fe(IV)) Chlamydia trachomatis Ribonucleotide Reductase
A class I ribonucleotide reductase (RNR) uses either a tyrosyl radical (Y•) or a Mn(IV)/Fe(III) cluster in its β subunit to oxidize a cysteine residue ∼ 35 Å away in its α subunit, generating a thiyl radical that abstracts hydrogen (H•) from the substrate. With either oxidant, the inter-subunit “hol...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931446/ https://ncbi.nlm.nih.gov/pubmed/23157728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309468s |
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