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Radical-translocation Intermediates and Hurdling of Pathway Defects in “Super-oxidized” (Mn(IV)/Fe(IV)) Chlamydia trachomatis Ribonucleotide Reductase

A class I ribonucleotide reductase (RNR) uses either a tyrosyl radical (Y•) or a Mn(IV)/Fe(III) cluster in its β subunit to oxidize a cysteine residue ∼ 35 Å away in its α subunit, generating a thiyl radical that abstracts hydrogen (H•) from the substrate. With either oxidant, the inter-subunit “hol...

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書誌詳細
主要な著者: Dassama, Laura M. K., Jiang, Wei, Varano, Paul T., Pandelia, Maria-Eirini, Conner, Denise A., Xie, Jiajia, Bollinger, J. Martin, Krebs, Carsten
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931446/
https://ncbi.nlm.nih.gov/pubmed/23157728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309468s
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