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Loss of Adenomatous Poliposis Coli-α3 Integrin Interaction Promotes Endothelial Apoptosis in Mice and Humans

RATIONALE: Pulmonary hypertension (PH) is characterized by progressive elevation in pulmonary pressure and loss of small pulmonary arteries. As bone morphogenetic proteins (BMPs) promote pulmonary angiogenesis by recruiting the Wnt/βcatenin pathway, we proposed that βcatenin activation could reduce...

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Detalhes bibliográficos
Main Authors: de Jesus Perez, Vinicio A., Yuan, Ke, Orcholski, Mark E., Sawada, Hirofumi, Zhao, Mingming, Li, Caiyun Grace, Tojais, Nancy F., Nickel, Nils, Rajagopalan, Viswanathan, Spiekerkoetter, Edda, Wang, Lingli, Dutta, Roop, Bernstein, Daniel, Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821702/
https://ncbi.nlm.nih.gov/pubmed/23011394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.267849
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