Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions

Previously, we reported that murine gammaherpesvirus-68 (M1-MHV-68) induces pulmonary artery (PA) neointimal lesions in S100A4-overexpressing, but not in wild-type (C57), mice. Lesions were associated with heightened lung elastase activity and PA elastin degradation. We now investigate a direct rela...

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Autors principals: Kim, Yu-Mee, Haghighat, Leila, Spiekerkoetter, Edda, Sawada, Hirofumi, Alvira, Cristina M., Wang, Lingli, Acharya, Swati, Rodriguez-Colon, Gabriela, Orton, Andrew, Zhao, Mingming, Rabinovitch, Marlene
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157285/
https://ncbi.nlm.nih.gov/pubmed/21763677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.051
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