Evaluation of the D3 Dopamine Receptor Selective Agonist/Partial Agonist PG01042 on L-Dopa Dependent Animal Involuntary Movements in Rats

The substituted 4-phenylpiperazine D3 dopamine receptor selective antagonist PG01037 ((E)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-(pyridin-2-yl)benzamide) was reported to attenuate L-dopa associated abnormal involuntary movements (AIMs) in unilaterally lesioned rats, a model of L-do...

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Autors principals: Riddle, Lindsay R., Kumar, Rakesh, Griffin, Suzy A., Grundt, Peter, Newman, Amy Hauck, Luedtke, Robert R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820002/
https://ncbi.nlm.nih.gov/pubmed/20850462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.09.011
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