Liver-specific Cholesteryl Ester Hydrolase deficiency attenuates sterol elimination in the feces and increases Atherosclerosis in Ldlr-/- Mice

OBJECTIVE: Liver is the major organ responsible for the final elimination of cholesterol from the body either as biliary cholesterol or as bile acids. Intracellular hydrolysis of lipoprotein-derived cholesteryl esters (CE) is essential to generate the free cholesterol (FC) required for this process....

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Hlavní autoři: Bie, Jinghua, Wang, Jing, Marqueen, Kathryn E, Osborne, Rachel, Kakiyama, Genta, Korzun, William, Ghosh, Siddhartha S, Ghosh, Shobha
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819806/
https://ncbi.nlm.nih.gov/pubmed/23744992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301634
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