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Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas
Maintenance of genomic integrity is essential for adult tissue homeostasis and defects in the DNA-damage response (DDR) machinery are linked to numerous pathologies including, cancer. Here we present evidence that the DDR exerts tumor suppressor activity in gliomas. We show that genes encoding compo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3818087/ https://ncbi.nlm.nih.gov/pubmed/21156285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.034 |
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