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53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma
The DNA-damage response (DDR) plays a crucial role in tumor development in different tissues. Here we show that p53-binding protein 1 (53BP1), a key element of the DDR, is heterozygously lost in approximately 20% of human glioblastoma multiforme (GBM) specimens, primarily of the Proneural subtype, a...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3771704/ https://ncbi.nlm.nih.gov/pubmed/22915756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0045 |
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