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ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth

ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2(−/−) pups died before weaning. This postnatal lethality was significantly enhanced in p53(+/−) background and both deletions are synthetic lethal. ASPP2(+/−) mice developed spontaneous tumors. The tumor onset...

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Autores principales: Vives, Virginie, Su, Jian, Zhong, Shan, Ratnayaka, Indrika, Slee, Elizabeth, Goldin, Robert, Lu, Xin
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472901/
https://ncbi.nlm.nih.gov/pubmed/16702401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.374006
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