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ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2(−/−) pups died before weaning. This postnatal lethality was significantly enhanced in p53(+/−) background and both deletions are synthetic lethal. ASPP2(+/−) mice developed spontaneous tumors. The tumor onset...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472901/ https://ncbi.nlm.nih.gov/pubmed/16702401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.374006 |
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