טוען...

53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice

p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both copies of 53BP1 greatly accelerates lymphomagenesis in a p53-null background, suggesting that 53BP1...

תיאור מלא

שמור ב:

מידע ביבליוגרפי
Main Authors:	Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, Frisk, Craig S., Ried, Thomas, Nussenzweig, Andre, Chen, Junjie
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology 2005
נושאים:	Mammalian Genetic Models with Minimal or Complex Phenotypes
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1280262/ https://ncbi.nlm.nih.gov/pubmed/16260621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.22.10079-10086.2005
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice

פריטים דומים