53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice

p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both copies of 53BP1 greatly accelerates lymphomagenesis in a p53-null background, suggesting that 53BP1...

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Detalhes bibliográficos
Main Authors: Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, Frisk, Craig S., Ried, Thomas, Nussenzweig, Andre, Chen, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280262/
https://ncbi.nlm.nih.gov/pubmed/16260621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.22.10079-10086.2005
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