Carregant...
ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2(−/−) pups died before weaning. This postnatal lethality was significantly enhanced in p53(+/−) background and both deletions are synthetic lethal. ASPP2(+/−) mice developed spontaneous tumors. The tumor onset...
Guardat en:
| Autors principals: | , , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2006
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472901/ https://ncbi.nlm.nih.gov/pubmed/16702401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.374006 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|