Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer

BACKGROUND: The sigma-2 receptor has been validated as a biomarker for proliferating tumours. Second mitochondria-derived activator of caspase (Smac) is a protein released from mitochondria into the cytosol, leading to apoptosis. In this study, we investigated a sigma-2 ligand as a tumour-targeting...

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Bibliografiska uppgifter
Huvudupphovsmän: Zeng, C, Vangveravong, S, McDunn, J E, Hawkins, W G, Mach, R H
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817331/
https://ncbi.nlm.nih.gov/pubmed/24104966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.593
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