Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

BACKGROUND: Drug resistance is a significant problem in the treatment of ovarian cancer and can be caused by multiple mechanisms. Inhibition of apoptosis by the inhibitor of apoptosis proteins (IAPs) represents one such mechanism, and can be overcome by a mitochondrial protein called second mitochon...

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Detalhes bibliográficos
Main Authors: Garg, Gunjal, Vangveravong, Suwanna, Zeng, Chenbo, Collins, Lynne, Hornick, Mary, Hashim, Yassar, Piwnica-Worms, David, Powell, Matthew A, Mutch, David G, Mach, Robert H, Hawkins, William G, Spitzer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015918/
https://ncbi.nlm.nih.gov/pubmed/24602489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-50
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