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Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling

One major challenge in the development of cancer therapeutics is the selective delivery of the drugs to their cellular targets. In the case of pancreatic cancer, the σ-2 receptor is a unique target that triggers apoptosis upon activation. We have previously developed a series of chemical compounds w...

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書誌詳細
主要な著者: Spitzer, Dirk, Simon, Peter O., Kashiwagi, Hiroyuki, Xu, Jinbin, Zeng, Chenbo, Vangveravong, Suwanna, Zhou, Dong, Chang, Katherine, McDunn, Jonathan E., Hornick, John R., Goedegebuure, Peter, Hotchkiss, Richard S., Mach, Robert H., Hawkins, William G.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251632/
https://ncbi.nlm.nih.gov/pubmed/22065721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1354
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