Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling

One major challenge in the development of cancer therapeutics is the selective delivery of the drugs to their cellular targets. In the case of pancreatic cancer, the σ-2 receptor is a unique target that triggers apoptosis upon activation. We have previously developed a series of chemical compounds w...

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Bibliographic Details
Main Authors: Spitzer, Dirk, Simon, Peter O., Kashiwagi, Hiroyuki, Xu, Jinbin, Zeng, Chenbo, Vangveravong, Suwanna, Zhou, Dong, Chang, Katherine, McDunn, Jonathan E., Hornick, John R., Goedegebuure, Peter, Hotchkiss, Richard S., Mach, Robert H., Hawkins, William G.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251632/
https://ncbi.nlm.nih.gov/pubmed/22065721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1354
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