Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

BACKGROUND: We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashion. Here, we examined whether sigma-2 receptor ligands potentiate conventional...

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Detalhes bibliográficos
Main Authors: Kashiwagi, Hiroyuki, McDunn, Jonathan E, Simon, Peter O, Goedegebuure, Peter S, Vangveravong, Suwanna, Chang, Katherine, Hotchkiss, Richard S, Mach, Robert H, Hawkins, William G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669042/
https://ncbi.nlm.nih.gov/pubmed/19323815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-24
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