Sigma-2 ligands induce tumour cell death by multiple signalling pathways

BACKGROUND: The sigma-2 receptor has been identified as a biomarker of proliferating cells in solid tumours. In the present study, we studied the mechanisms of sigma-2 ligand-induced cell death in the mouse breast cancer cell line EMT-6 and the human melanoma cell line MDA-MB-435. METHODS: EMT-6 and...

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Detalhes bibliográficos
Main Authors: Zeng, C, Rothfuss, J, Zhang, J, Chu, W, Vangveravong, S, Tu, Z, Pan, F, Chang, K C, Hotchkiss, R, Mach, R H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322954/
https://ncbi.nlm.nih.gov/pubmed/22251921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.602
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