S6K1(−/−)/S6K2(−/−) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is inhibited by the bacterial macrolide rapamycin, which binds to and inactivates the mammalian target of rapamycin, an S6K k...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Pende, Mario, Um, Sung Hee, Mieulet, Virginie, Sticker, Melanie, Goss, Valerie L., Mestan, Jurgen, Mueller, Matthias, Fumagalli, Stefano, Kozma, Sara C., Thomas, George
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2004
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3112-3124.2004
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