The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

The immunosuppressive agent rapamycin induces inactivation of p70s6k with no effect on other mitogen-activated kinases. Here we have employed a combination of techniques, including mass spectrometry, to demonstrate that this effect is associated with selective dephosphorylation of three previously u...

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Vydáno v:EMBO J
Hlavní autoři: Pearson, R B, Dennis, P B, Han, J W, Williamson, N A, Kozma, S C, Wettenhall, R E, Thomas, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1995
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394637/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7489717/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00212.x
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