S6K1(−/−)/S6K2(−/−) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is inhibited by the bacterial macrolide rapamycin, which binds to and inactivates the mammalian target of rapamycin, an S6K k...

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Detalhes bibliográficos
Main Authors: Pende, Mario, Um, Sung Hee, Mieulet, Virginie, Sticker, Melanie, Goss, Valerie L., Mestan, Jurgen, Mueller, Matthias, Fumagalli, Stefano, Kozma, Sara C., Thomas, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC381608/
https://ncbi.nlm.nih.gov/pubmed/15060135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3112-3124.2004
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