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S6K1(−/−)/S6K2(−/−) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is inhibited by the bacterial macrolide rapamycin, which binds to and inactivates the mammalian target of rapamycin, an S6K k...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Principais autores: Pende, Mario, Um, Sung Hee, Mieulet, Virginie, Sticker, Melanie, Goss, Valerie L., Mestan, Jurgen, Mueller, Matthias, Fumagalli, Stefano, Kozma, Sara C., Thomas, George
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381608/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060135/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3112-3124.2004
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