P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little work has focused on the contribution of Pgp expressed in intracellular organelles to drug resistance. This investiga...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yamagishi, Tetsuo, Sahni, Sumit, Sharp, Danae M., Arvind, Akanksha, Jansson, Patric J., Richardson, Des R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814770/
https://ncbi.nlm.nih.gov/pubmed/24062304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514091
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