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P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration
Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little work has focused on the contribution of Pgp expressed in intracellular organelles to drug resistance. This investiga...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814770/ https://ncbi.nlm.nih.gov/pubmed/24062304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514091 |
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