Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Chagas disease, caused by the eukaryotic (protozoan) parasite Trypanosoma cruzi, is an alarming emerging global health problem with no clinical drugs available to treat the chronic stage. Azole inhibitors of sterol 14α-demethylase (CYP51) were proven effective against Chagas, and antifungal drugs po...

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Main Authors: Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Alexander, Paul W., Chaplin, Jason H., Keenan, Martine, Charman, Susan A., Perez, Catherine J., Waterman, Michael R., Chatelain, Eric, Lepesheva, Galina I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814756/
https://ncbi.nlm.nih.gov/pubmed/24047900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497990
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