Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway

Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a mutation in one of the mismatch repair genes ML...

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Main Authors: Smith, Catherine E., Mendillo, Marc L., Bowen, Nikki, Hombauer, Hans, Campbell, Christopher S., Desai, Arshad, Putnam, Christopher D., Kolodner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814310/
https://ncbi.nlm.nih.gov/pubmed/24204293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003869
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