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Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
Inactivating mutations affecting key mismatch repair (MMR) components lead to microsatellite instability (MSI) and cancer. However, a number of patients with MSI-tumors do not present alterations in classical MMR genes. Here we discovered that specific missense mutations in the MutL homolog MLH2, wh...
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| Publicado no: | Commun Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7730388/ https://ncbi.nlm.nih.gov/pubmed/33303966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01481-4 |
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