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Molecular structure of β-amyloid fibrils in Alzheimer’s disease brain tissue

In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Detailed structural information about Aβ assemblies in the human brain has been lacking. Here, we investigate structures of b...

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Main Authors: Lu, Jun-Xia, Qiang, Wei, Yau, Wai-Ming, Schwieters, Charles D., Meredith, Stephen C., Tycko, Robert
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814033/
https://ncbi.nlm.nih.gov/pubmed/24034249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.035
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