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Molecular structure of β-amyloid fibrils in Alzheimer’s disease brain tissue

In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Detailed structural information about Aβ assemblies in the human brain has been lacking. Here, we investigate structures of b...

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Hlavní autoři: Lu, Jun-Xia, Qiang, Wei, Yau, Wai-Ming, Schwieters, Charles D., Meredith, Stephen C., Tycko, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814033/
https://ncbi.nlm.nih.gov/pubmed/24034249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.035
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