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Molecular structure of β-amyloid fibrils in Alzheimer’s disease brain tissue

In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Detailed structural information about Aβ assemblies in the human brain has been lacking. Here, we investigate structures of b...

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Detalhes bibliográficos
Main Authors: Lu, Jun-Xia, Qiang, Wei, Yau, Wai-Ming, Schwieters, Charles D., Meredith, Stephen C., Tycko, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814033/
https://ncbi.nlm.nih.gov/pubmed/24034249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.035
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