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Coexisting Order and Disorder Within a Common 40-Residue Amyloid-β Fibril Structure in Alzheimer's Disease Brain Tissue

Fibrils formed by 40- and 42-residue amyloid-β (Aβ40 and Aβ42) peptides exhibit molecular-level structural polymorphisms. A recent screen of fibrils derived from brain tissue of Alzheimer's disease patients revealed a single predominant Aβ40 polymorph. We present solid state nuclear magnetic re...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Ghosh, Ujjayini, Yau, Wai-Ming, Tycko, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953852/
https://ncbi.nlm.nih.gov/pubmed/29707712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc01967c
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