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Depletion of amyloid‐β peptides from solution by sequestration within fibril‐seeded hydrogels

Aggregation of amyloid‐β (Aβ) peptides in brain tissue leads to neurodegeneration in Alzheimer's disease (AD). Regardless of the kinetics or detailed mechanisms of Aβ aggregation, aggregation can only occur if Aβ concentrations exceed their local equilibrium solubility values. We propose that e...

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Bibliografiske detaljer
Udgivet i:Protein Sci
Main Authors: Yau, Wai‐Ming, Tycko, Robert
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032349/
https://ncbi.nlm.nih.gov/pubmed/29417648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3387
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