Human Herpesvirus 6 U69 Kinase Phosphorylates the Methylenecyclopropane Nucleosides Cyclopropavir, MBX 2168, and MBX 1616 to Their Monophosphates

Dihydroxymethyl and monohydroxymethyl methylenecyclopropane nucleosides are effective inhibitors of both variants of human herpesvirus 6 (HHV-6). We investigated involvement of HHV-6 U69 protein kinase in their mechanism of action. Phosphorylation of the dihydroxymethyl analogue cyclopropavir and mo...

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Bibliographic Details
Main Authors: Komazin-Meredith, Gloria, Cardinale, Steven C., Williams, John D., Peet, Norton P., Prichard, Mark N., Bowlin, Terry L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811273/
https://ncbi.nlm.nih.gov/pubmed/23979753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00978-13
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