Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis

Phosphorylation of BCL-2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL-2 predominantly localized to the endoplasmic reticulum (ER) and tested whether phosphorylation would control its activity at this organelle, where Ca(2+) dynamics serve as a criti...

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Bibliographic Details
Main Authors: Bassik, Michael C, Scorrano, Luca, Oakes, Scott A, Pozzan, Tullio, Korsmeyer, Stanley J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC380968/
https://ncbi.nlm.nih.gov/pubmed/15010700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600104
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