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Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis

Phosphorylation of BCL-2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL-2 predominantly localized to the endoplasmic reticulum (ER) and tested whether phosphorylation would control its activity at this organelle, where Ca(2+) dynamics serve as a criti...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Bassik, Michael C, Scorrano, Luca, Oakes, Scott A, Pozzan, Tullio, Korsmeyer, Stanley J
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC380968/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15010700/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600104
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