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Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis
Phosphorylation of BCL-2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL-2 predominantly localized to the endoplasmic reticulum (ER) and tested whether phosphorylation would control its activity at this organelle, where Ca(2+) dynamics serve as a criti...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC380968/ https://ncbi.nlm.nih.gov/pubmed/15010700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600104 |
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