Bcl-2 regulates store-operated Ca(2+) entry to modulate ER stress-induced apoptosis

Ca(2+) plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca(2+) across the ER membrane, but the exact effect of Bcl-2 on Ca(2+) levels remains controversial. Store-operated Ca(2+) entry (SOCE), a major...

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Publicado en:Cell Death Discov
Autores principales: Chiu, Wen-Tai, Chang, Heng-Ai, Lin, Yi-Hsin, Lin, Yu-Shan, Chang, Hsiao-Tzu, Lin, Hsi-Hui, Huang, Soon-Cen, Tang, Ming-Jer, Shen, Meng-Ru
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841437/
https://ncbi.nlm.nih.gov/pubmed/29531834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0039-4
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