Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

[Image: see text] Bromodomains (BRDs) are epigenetic readers that recognize acetylated-lysine (KAc) on proteins and are implicated in a number of diseases. We describe a virtual screening approach to identify BRD inhibitors. Key elements of this approach are the extensive design and use of substruct...

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Detalhes bibliográficos
Main Authors: Vidler, Lewis R., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Martin, Sarah, Tomsett, Michael, Woodward, Hannah, Brown, Nathan, Knapp, Stefan, Hoelder, Swen
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807807/
https://ncbi.nlm.nih.gov/pubmed/24090311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4011302
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