Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design

We describe a computer-based protocol to design protein mutations increasing binding affinity between ligand and its receptor. The method was applied to mutate interferon-γ receptor 1 (IFN-γ-Rx) to increase its affinity to natural ligand IFN-γ, protein important for innate immunity. We analyzed all...

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Detalhes bibliográficos
Main Authors: Mikulecký, Pavel, Černý, Jiří, Biedermannová, Lada, Petroková, Hana, Kuchař, Milan, Vondrášek, Jiří, Malý, Petr, Šebo, Peter, Schneider, Bohdan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807708/
https://ncbi.nlm.nih.gov/pubmed/24199198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/752514
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