Redesigning Protein Cavities as a Strategy for Increasing Affinity in Protein-Protein Interaction: Interferon-γ Receptor 1 as a Model

Combining computational and experimental tools, we present a new strategy for designing high affinity variants of a binding protein. The affinity is increased by mutating residues not at the interface, but at positions lining internal cavities of one of the interacting molecules. Filling the cavitie...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biomed Res Int
मुख्य लेखकों: Černý, Jiří, Biedermannová, Lada, Mikulecký, Pavel, Zahradník, Jiří, Charnavets, Tatsiana, Šebo, Peter, Schneider, Bohdan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Hindawi Publishing Corporation 2015
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427845/
https://ncbi.nlm.nih.gov/pubmed/26060819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/716945
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