Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells

Engineered combinatorial libraries derived from small protein scaffolds represent a powerful tool for generating novel binders with high affinity, required specificity and designed inhibitory function. This work was aimed to generate a collection of recombinant binders of human interleukin-23 recept...

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Detalles Bibliográficos
Publicado en:Proteins
Main Authors: Kuchař, Milan, Vaňková, Lucie, Petroková, Hana, Černý, Jiří, Osička, Radim, Pelák, Ondřej, Šípová, Hana, Schneider, Bohdan, Homola, Jiří, Šebo, Peter, Kalina, Tomáš, Malý, Petr
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285857/
https://ncbi.nlm.nih.gov/pubmed/24549990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24472
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