ABD-Derived Protein Blockers of Human IL-17 Receptor A as Non-IgG Alternatives for Modulation of IL-17-Dependent Pro-Inflammatory Axis

Interleukin 17 (IL-17) and its cognate receptor A (IL-17RA) play a crucial role in Th17 cells-mediated pro-inflammatory pathway and pathogenesis of several autoimmune disorders including psoriasis. IL-17 is mainly produced by activated Th-17 helper cells upon stimulation by IL-23 and, via binding to...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Hlavničková, Marie, Kuchař, Milan, Osička, Radim, Vaňková, Lucie, Petroková, Hana, Malý, Michal, Černý, Jiří, Arenberger, Petr, Malý, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213189/
https://ncbi.nlm.nih.gov/pubmed/30304852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103089
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