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Preclinical Studies of Apogossypolone, a Novel Pan Inhibitor of Bcl-2 and Mcl-1, Synergistically Potentiates Cytotoxic Effect of Gemcitabine in Pancreatic Cancer Cells
OBJECTIVE: Overexpression of antiapoptotic Bcl-2 family proteins confers resistance to conventional therapy in pancreatic cancer patients. Apogossypolone (ApoG2) is an analogue of (−)–gossypol, exhibiting binding activity with K(i) values of 35 nmol/L for Bcl-2 and 25 nmol/L for Mcl-1. The present s...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807128/ https://ncbi.nlm.nih.gov/pubmed/19823097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e3181bb95e7 |
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