MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function

Small molecule inhibitors (SMIs) of MDM2 are known to restore the apoptotic and cell cycle regulatory functions of p53 by disrupting the MDM2-p53 interaction. In principle, these SMIs are not effective against tumours with mut-p53, which is known to be present in approximately 50% of all cancers. In...

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Main Authors: Azmi, Asfar S., Aboukameel, Amro, Banerjee, Sanjeev, Wang, Zhiwei, Mohammad, Momin, Wu, Jack, Wang, Shaomeng, Yang, Dajun, Philip, Philip A., Sarkar, Fazlul H., Mohammad, Ramzi M.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106027/
https://ncbi.nlm.nih.gov/pubmed/20156675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.01.015
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