MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy

Zinc plays a crucial role in the biology of p53 in that p53 binds to DNA through a structurally complex domain stabilized by zinc atom. The p53 negative regulator MDM2 protein also carries a C-terminal RING domain that coordinates two zinc atoms which are responsible for p53 nuclear export and prote...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Azmi, Asfar S., Philip, Philip A., Beck, Frances W.J., Wang, Zhiwei, Banerjee, Sanjeev, Wang, Shaomeng, Yang, Dajun, Sarkar, Fazlul H., Mohammad, Ramzi M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000878/
https://ncbi.nlm.nih.gov/pubmed/20818437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.403
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados