Preclinical Studies of Apogossypolone, a Novel Pan Inhibitor of Bcl-2 and Mcl-1, Synergistically Potentiates Cytotoxic Effect of Gemcitabine in Pancreatic Cancer Cells

OBJECTIVE: Overexpression of antiapoptotic Bcl-2 family proteins confers resistance to conventional therapy in pancreatic cancer patients. Apogossypolone (ApoG2) is an analogue of (−)–gossypol, exhibiting binding activity with K(i) values of 35 nmol/L for Bcl-2 and 25 nmol/L for Mcl-1. The present s...

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Hoofdauteurs: Banerjee, Sanjeev, Choi, Minsig, Aboukameel, Amro, Wang, Zhiwei, Mohammad, Mussop, Chen, Jianyong, Yang, Dajun, Sarkar, Fazlul H., Mohammad, Ramzi M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807128/
https://ncbi.nlm.nih.gov/pubmed/19823097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e3181bb95e7
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