Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo

Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol. The principal objective of this study was to compare stability and toxicity between ApoG2 and gossypol, and to evaluate anti-lymphoma activity of ApoG2 in vitro and in vivo. ApoG2 shows better stability when compared with a racemic...

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Hauptverfasser: Sun, Yuan, Wu, Jack, Aboukameel, Amro, Banerjee, Sanjeev, Arnold, Alan A., Chen, Jianyong, Nikolovska-Coleska, Zaneta, Lin, Yanqiong, Ling, Xiaolan, Yang, Dajun, Wang, Shaomeng, Al-Katib, Ayad, Mohammad, Ramzi M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106024/
https://ncbi.nlm.nih.gov/pubmed/18769131
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