Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-X(L )and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting Bcl-2 family proteins, Apogossypolone (ApoG2) using follicu...

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Bibliographic Details
Main Authors: Arnold, Alan A, Aboukameel, Amro, Chen, Jianyong, Yang, Dajun, Wang, Shaomeng, Al-Katib, Ayad, Mohammad, Ramzi M
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265299/
https://ncbi.nlm.nih.gov/pubmed/18275607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-20
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