Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55

Dopamine D3 receptor (D3R)-selective compounds may be useful medications for cocaine dependence. In this study, we identified two novel arylamide phenylpiperazines, OS-3-106 and WW-III-55, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. OS-3-106 and WW-III-55 have 115- and 8...

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Bibliografski detalji
Glavni autori: Cheung, Timothy H. C., Loriaux, Amy L., Weber, Suzanne M., Chandler, Kayla N., Lenz, Jeffrey D., Schaan, Romina F., Mach, Robert H., Luedtke, Robert R., Neisewander, Janet L.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Neuropharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807071/
https://ncbi.nlm.nih.gov/pubmed/24018640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.202911
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