Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53(−/−) mouse model and primary human leukemia cells

Chronic lymphocytic leukemia (CLL) patients with deletion of chromosome 17p, where the tumor suppressor p53 gene is located, often develop more aggressive disease with poor clinical outcomes. To investigate the underlying mechanisms responsible for the highly malignant phenotype of 17p- CLL and to f...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Liu, Jinyun, Chen, Gang, Feng, Li, Zhang, Wan, Pelicano, Helene, Wang, Feng, Ogasawara, Marcia A, Lu, Weiqin, Amin, Hesham M., Croce, Carlo M., Keating, Michael J., Huang, Peng
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806892/
https://ncbi.nlm.nih.gov/pubmed/23608884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.125
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