p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL

Deletion of the short-arm of chromosome 17 (17p-) is one of the most critical genetic alterations used in chronic lymphocytic leukemia (CLL) risk stratification. The tumor suppressor TP53 maps to this region, and its loss or mutation accelerates CLL progression, hampers response to chemotherapy and...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Lee, H J, Gallardo, M, Ma, H, Zhang, X, Larsson, C A, Mejia, A, Hornbaker, M J, Qi, Y, Su, X, Pageon, L R, Quintas-Cardama, A, Post, S M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141356/
https://ncbi.nlm.nih.gov/pubmed/27284738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2016.41
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